Biotechnology plays an important role in many of today’s industries. Not only modern synthetic biology and biomaterials, but also the food industry, agricultural and pharmaceutical research, point-of-care diagnostics, and personalized and regenerative medicine all rely on basic principles of biotechnology as the foundation of their operations.
Tissue engineering and bioprinting present potential opportunities for commercial and organ research. Functional organ structures enable in vivo procedures, while microfluidics enable the functions of physiologically -active cells on a chip. The advent of lab-on-a-chip technology will make organ, bone, and health-on-a-chip technology a reality.
New developments in bio and gene technology, as well as in diagnostics and medical technology, require advanced analysis methods. The innovative synthesis of novel active substances and medicines and promising personalized medical therapies and gene therapies are decisively dependent up on the performance of biotechnological analyses for their results. These technologies range from sample preparation methods to liquid handling, from single-use-systems and disposables to the instrumental analysis of mass spectrometry and imaging processes like microscopy, from the micro and nano technology of immunological and molecular biological procedures of bioreactors, to assays and chip technologies, from high-throughput screening and drug discovery of laboratory automation to data management. Such system solutions enable short analysis and trial periods, detailed interpretative opportunities for measurement results, and availability of integral data necessary for users to achieve their research objectives.
Potential of biotechnology
Like most other areas, biotechnology developments are the subject of intense study, resulting in rapid advancements in the field. Whether red, green, or white biotechnology, many interdisciplinary solutions substantially influence our lives today.
Biotechnological processes have become a prerequisite for sustainable research, for example, for the development of algae as an effective carbon dioxide and biomass substance-producing agent. The bio-economic role of algae biotechnology is becoming increasingly evident in many areas of research. The spectrum ranges from the production of pharmaceutical and cosmetically effective substances to nutritional, supplemental, and feed products, to renewable aircraft fuel.
Moreover, the isolation and characterization of natural substances and new plant-based secondary metabolites, as well as the solving of biosyntheses, are becoming more and more important for the research of new substances and the production of pharmaceuticals and natural cosmetics.
Next-generation- technologies are setting higher standards in the commercial and organ research industry. The aim is to set new and innovative therapeutic standards for surgery and vascular surgery, tumor treatment, and even dermatology. In doing so, the immune system of the patient is intended to react to the specific tumor in a targeted and specific manner. The body’s repair mechanisms are to be specifically activated. Faster diagnoses and better therapies should successfully improve medical treatment outcomes and make treatments safer. At the center of all considerations are individual diagnostics and personalized functional processes.
Biofabrication und biotesting
DNA arrays for transcriptomics and proteomics methods contribute to the development of materials and substances for intelligent implant application. Cellular biological trial procedures and vitality tests are already being implemented in science to evaluate bio-compatibility with human cells. Isolated stem cells act as various qualified testing cells for 2D or 3D biotesting.
Aptamers are single-stranded oligonucleotides capable of binding targeted molecules with high affinity and specificity. The specific binding between aptamer and target molecules can lead to the purification of the target molecule or can be used for the detection of proteins and bacteria. Aptamers can be utilized for diagnostic purposes for disease-specific markers.
Aptamer-based processes are also becoming increasingly more applicable in the area of food sensing, for example, during aptamer-based affinity enhancement with subsequent specific real-time detection. In addition, the aptamer offers a promising alternative for current animal welfare provisions, as its utilization can reduce animal testing for scientific purposes.
In the area of life sciences, computer-aided analysis and evaluation methods are invaluable for solving molecular connections, of particular importance in bioinformatics. Next-generation methods are in high demand, especially in synthetic biology, specifically for computer-aided substance design and point-of-care diagnostics. Large volumes of data can be generated at a faster rate with new ultra-high- throughput sequencing methods.
The meaningful use and handling of this massive amount of data, the necessity of archiving and storing testing material subject to legislation and best practices, and ever-increasing demands and increasing costs are all central to the discussion of fast data availability, efficiency improvement, and security. Biobanks and peptide libraries, automation and automated systems, LIMS, software, and smart laboratory devices are, therefore, invaluable tools in the field of life sciences, particularly against the backdrop of increasing digitization.
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